https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Parapneumonic Effusions Are Characterized by Elevated Levels of Neutrophil Extracellular Traps https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48718 Wed 29 Mar 2023 16:01:20 AEDT ]]> Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18353 Wed 24 Jun 2015 13:30:14 AEST ]]> IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25787 Wed 11 Apr 2018 16:15:49 AEST ]]> Clinical assessment of speech correlates well with lung function during induced bronchoconstriction https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27558 Wed 11 Apr 2018 13:06:08 AEST ]]> Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: a position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34064 Wed 04 Sep 2019 10:06:34 AEST ]]> Thoracic ultrasound recognition of competence: a position paper of the Thoracic Society of Australia and New Zealand https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34462 Wed 04 Sep 2019 10:04:55 AEST ]]> A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49742 Tue 30 May 2023 15:22:46 AEST ]]> Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45701 Tue 28 Mar 2023 15:44:53 AEDT ]]> The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47646 Tue 24 Jan 2023 14:51:39 AEDT ]]> Cryobiopsy for Identification of Usual Interstitial Pneumonia and Other Interstitial Lung Disease Features: Further Lessons from COLDICE, a Prospective Multicenter Clinical Trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41876 Tue 16 Aug 2022 14:17:45 AEST ]]> Biomarker signatures for progressive idiopathic pulmonary fibrosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47057 Tue 13 Dec 2022 15:32:32 AEDT ]]> TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47015 Tue 13 Dec 2022 11:55:35 AEDT ]]> Circulating RNA differences between patients with stable and progressive idiopathic pulmonary fibrosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38777 Tue 08 Feb 2022 12:17:52 AEDT ]]> Gastroesophageal reflux and antacid therapy in IPF: Analysis from the Australia IPF Registry https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46902 8. Overall, there was no difference in survival or disease progression, regardless of antacid treatment, GORD diagnosis or GORD symptoms. Conclusions: Neither the use of antacid therapy nor the presence of GORD symptoms affects longer term outcomes in IPF patients. This contributes to the increasing evidence that antacid therapy may not be beneficial in IPF patients and that GORD directed therapy should be considered on an individual basis to treat the symptoms of reflux.]]> Tue 06 Dec 2022 16:07:24 AEDT ]]> Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46906 Tue 06 Dec 2022 16:07:23 AEDT ]]> The effect of inhaled corticosteroids on bone mineral density measured by quantitative ultrasonography in an older population https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35998 Thu 17 Mar 2022 14:39:42 AEDT ]]> Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34569 Thu 04 Nov 2021 10:38:24 AEDT ]]> Ventilation heterogeneity is a treatable trait in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55058 Mon 08 Apr 2024 09:43:57 AEST ]]> Mepolizumab effectiveness and identification of super-responders in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40118 Fri 22 Jul 2022 13:48:23 AEST ]]> Randomised controlled trial for the titration of oral corticosteroids using markers of inflammation in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53104 Fri 17 Nov 2023 11:38:03 AEDT ]]> Inhaled pirfenidone solution (AP01) for IPF: A randomised, open-label, dose-response trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51684 Fri 15 Sep 2023 09:37:14 AEST ]]> The emerging role of neutrophil extracellular traps in respiratory disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46163 Fri 11 Nov 2022 19:34:08 AEDT ]]> Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46097 P < 0.05, n = 5–8). The targeting of cGAS also attenuated etoposide-induced senescence in Ctrl-LFs (P < 0.05, n = 5–8). Levels of mitochondrial DNA (mDNA) detected by qPCR in the cytosol and medium of IPF-LFs or senescence-induced Ctrl-LFs were higher than Ctrl-LFs at baseline (P < 0.05, n = 5–7). The addition of DNAse I (100 U/ml) deaccelerated IPF-LF senescence (P < 0.05, n = 5), whereas ectopic mDNA or the induction of endogenous mDNA release augmented Ctrl-LF senescence in a cGAS-dependent manner (P < 0.05, n = 5). In conclusion, we provide evidence that cGAS reinforces lung fibroblast senescence involving damaged self DNA. The targeting of cGAS to supress senescent-like responses may have potential important therapeutic implications in the treatment of IPF.]]> Fri 11 Nov 2022 11:23:00 AEDT ]]> Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55279 Fri 10 May 2024 16:14:04 AEST ]]> Toll-like receptor 7 is reduced in severe asthma and linked to an altered microRNA profile https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24497 Ex vivo knockdown of these microRNAs restored TLR7 expression with concomitant augmentation of virus-induced IFN production. Conclusions: In severe asthma, TLR7 deficiency drives impaired innate immune responses to virus by AMs. Blocking a group of microRNAs that are up-regulated in these cells can restore antiviral innate responses, providing a novel approach for therapy in asthma.]]> Fri 01 Apr 2022 09:26:07 AEDT ]]>